We just ran our first play test. Fighters and Rogues loved that removal of PTD. They could easily wait until they could land a good shot, and hit the NPC with enough to usually drop it. Some times it would be negated by a skill, but more often than not, they could land it. I was on the receiving end of several 500 Body and several of the Slays/Assassinates that I had to either eat, or negate (or a minion was close enough to me to Intercept). But even when they did not land, most players had Mediate III and could go get it back during the fight (1 minute) and come back in to try to land the hit again.
It really is something that players must playtest. Theory-crafting it does not do it any justice in the least.